What is Hydrocodone?

Hydrocodone is a well-known semi synthetic substance generally made by modifying codeine, a natural substance detected in the plant (opium poppy). Hydrocodone helps to manage severe conditions, such as-

• Pain Management- This medication is FDA approved for alleviating pain severe enough to need an opioid and when other pain killers haven’t worked or are not able to tolerate.

• Cough Suppression- It lowers activity in the area of the brain that is responsible for coughing.

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Mechanism of action of Hydrocodone

Receptor Binding- A semi-synthetic opioid, hydrocodone has a strong affinity for the mu-opioid receptor, although it can also bind to delta and kappa opioid receptors at higher dosages.

Signal Modification- Hydrocodone changes pain signals by binding to these receptors presented in the spinal cord and brain. It blocks the pathways of ascending pain and alters how the brain perceives and reacts to the pain.

Neurotransmitter Inhibition- The initial impact is the presynaptic inhibition of the release of neurotransmitter, which lowers the pain signals transmission between CNS.

CNS Depression- Additionally, the stimulation of opioid receptors causes broad CNS depression, which can result in euphoria, sedation, and respiratory depression.

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Active and Inactive Ingredients of Hydrocodone

Active Ingredients- Hydrocodone bitrate, Ibuprofen, Acetaminophen, and Homatropine methylbromide.

Inactive Ingredients- 

• Disintegrants- Crospovidone, croscarmellose sodium, sodium starch glycolate
• Binding agents- Microcrystalline cellulose, povidone, corn starch (pregelatinized starch)
• Fillers- Dibasic calcium phosphate, lactose monohydrate, sucrose
• Lubricants- Stearic acid, magnesium stearate, talc
• Colorants- FD&C Blue #1 aluminum lake, Various FD&C (FD&C Red #3, FD&C Yellow #5, etc.), and D&C colorants (D&C Red #27 aluminum lake, D&C Yellow #10 lakes, etc.)
• Other- Coating agent (hypromellose), preservative (methylparaben), A flow agent (colloidal silicon dioxide).

History And FDA Status of Hydrocodone

Early marketing synthesis- Hydrocodone was initially synthesized by Helene Lowenheim and Carl Mannich in 1920. Germany marked this medication in 1924 under the Dicodid (brand version).

FDA approval- Hydrocodone got first approval for usage in the United States as a cough suppressant (antitussive) on March 23, 1943, under the Hycodan (brand name).

Combined Medications- The majority of hydrocodone medicines have historically been combination formulations with other non-opioid analgesics, such as ibuprofen (Vicoprofen) or acetaminophen (brand names including Vicodin, Norco, and Lortab).

It was originally believed that adding a second medication would assist prevent addiction and overdose.

FDA-approved indications

Management of pain- Hydrocodone is FDA approved to manage severe chronic pain that needs continuous ATC opioid analgesia and not treated by other treatments.

Cough Suppression- This medication is used in mixture formulations to manage nonproductive cough in adults. Due to dangers in pediatric populations, the FDA required label revisions for prescription cough and cold drugs containing hydrocodone or codeine in 2018, limiting their use to people 18 years of age and older.

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Colors, Imprints, and other details of Hydrocodone

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Potential side effects of Hydrocodone

Along with the needed effects, Hydrocodone can be the reason for undesired adverse reactions. If you notice any of them, you must consult an experienced healthcare expert. Here are the most common side effects of Hydrocodone, such as

• Lightheadedness and dizziness
• Vomiting and nausea
• Trouble sleeping
• Dry mouth, headache

Severe side effects

Signs of an allergic reaction, such as rash, hives, difficulty swallowing, or swelling of the body parts.

• Irregular heartbeat or chest pain
• Liver damage (mainly when this medication is combined with acetaminophen).
• Significant mood swings or confusion
• Difficult or slowed breathing

These side effects may go away as your body gets used to the medication. You need to be cautious after you buy Hydrocodone online.

Warnings and precautions associated with Hydrocodone

Abuse, addiction, and misuse- This medication is a schedule II (controlled substance) with a greater chance for developing psychological and physical dependence. This is why, if you plan to order Hydrocodone online, you should start with the smallest dose for the shortest duration.

Respiratory depression- If you take Hydrocodone with other CNS depressants, increasing the dosage, this is the most major risk. Patients already suffering with pre-existing respiratory issues such as COPD or asthma are at higher risk.

Ingestion by mistake- Even a single dosage of hydrocodone, mainly by a kid can be harmful. This is why you should keep this medication out of the reach of others. Disposing unused or expired medication via a take-back program or flushing it is a good idea.

Diving or operating heavy equipment- Hydrocodone may cause sleepiness and impair monster coordination and mental awareness. You need to avoid driving a car and operating heavy equipment until you know how this medication impacts you from inside.

Head Injury- Opioids may enhance pressure in the head and obscure the patient’s clinical course with brain tumors or head injuries.

Allergies- Avoid using Hydrocodone if you have a known allergy to any of its components, other opioids, or any of the inactive ingredients.

If you follow these instructions after buying Hydrocodone online, you will see the magical impact of this medication.

Dosing details of Hydrocodone

Hydrocodone is generally prescribed in the mixture with other medications such as ibuprofen or acetaminophen.

IR Pill Acetaminophen for modest to acute pain

Primary dosage started with 1-2 pills every 4-6 hours as required. Generally 6-8 pills, not exceeding 4000 mg of acetaminophen.

IR Oral solution for cough or pain relief- Primarily started with 5 mL for cough or 15 mL for pain, every 4-6 hours as required. The highest daily dosage varies by product; such as generally not exceeding 30-90 mL per day.

ER Pills/Capsules for severe chronic pain (patients who can tolerate opioids)

Initially started at 10 to 20 mg every 12-24 hours based on the formulation. The maximum regular dosage must be determined and adjusted by an experienced healthcare expert.

These details are based on general dosing guides. To get proper dosage instructions, buy Hydrocodone online from an authentic source.

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Conclusion

Hydrocodone can be helpful and manage your pain along with cough if it’s used with proper caution and prescribed for short-term usage. This medication is not for kids under 6 years old or older people above 65 years old. To prevent yourself from overdose, take the required dosage of this medication.

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FAQs (Frequently Asked Questions)

Can I consume alcoholic beverages while taking Hydrocodone?

You should avoid taking alcoholic beverages while taking Hydrocodone as this combination may impair your breathing, increase the risk of severe side effects, and enhance sleepiness.

Can this medication cause dependence or addiction?

Yes, long-term usage of this medication can be the reason for addiction or physical dependence. You should avoid taking this medication abruptly without asking your healthcare expert as it may cause undesired withdrawal symptoms.

What are the symptoms of an overdose?

The symptoms of overdose may include shallow or slow breathing, confusion, extreme drowsiness, clammy and cold skin, loss of consciousness, and small pupils. After buying Hydrocodone online, if you notice any of these symptoms, let your healthcare expert know.

What are the common side effects of Hydrocodone?

The common side effects of Hydrocodone may include constipation, dizziness, sleepiness, lightheadedness, headache, vomiting, and fatigue.